Last updated: 25th April 2024.
Choudhary P, Ronkainen J, Carson J, Karhunen V, …, Huang RC, Sebert S (2024). Developmental origins of psycho-cardiometabolic multimorbidity in adolescence and their underlying pathways through methylation markers: a two-cohort study. Eur Child Adolesc Psychiatry. doi:10.1007/s00787-024-02390-1.
Yarmolinsky J, Robinson JW, Mariosa D, Karhunen V, …, Martin RM (2024). Association between circulating inflammatory markers and adult cancer risk: a Mendelian randomization analysis. EBioMedicine. doi:10.1016/j.ebiom.2024.104991.
de La Harpe R, Zagkos L, Gill D, Cronjé HT, Karhunen V (2024). Cerebrospinal and Brain Proteins Implicated in Neuropsychiatric and Risk Factor Traits: Evidence from Mendelian Randomization. Biomedicines. doi:10.3390/biomedicines12020327.
Choudhary P, Monasso GS, Karhunen V, …, Felix JF, Sebert S (2023). Maternal educational attainment in pregnancy and epigenome-wide DNA methylation changes in the offspring from birth until adolescence. Mol Psychiatry. doi:10.1038/s41380-023-02331-5.
Mustafa R, Ghanbari M, Karhunen V, Evangelou M, Dehghan A (2023). Phenome-wide association study on miRNA-related sequence variants: the UK Biobank. Hum Genomics. doi:10.1186/s40246-023-00553-w.
He Y, Karhunen V, Pulakka A, Kantomaa M, Sebert S (2023). A bidirectional Mendelian randomisation study to evaluate the relationship between body constitution and hearing loss. Sci Rep. doi:10.1038/s41598-023-44735-x.
Cronjé HT, Karhunen V, Hovingh GK, …, Gill D (2023). Genetic evidence implicating natriuretic peptide receptor-3 in cardiovascular disease risk: a Mendelian randomization study. BMC Med. doi:10.1186/s12916-023-02867-x.
Wang M, Zhang Z, Georgakis MK, Karhunen V, Liu D (2023). The Impact of Genetically Proxied AMPK Activation, the Target of Metformin, on Functional Outcome Following Ischemic Stroke. J Stroke. doi:10.5853/jos.2022.03230.
Wang M, Zhang Z, Liu D, Karhunen V, …, Liu M (2023). Soluble adhesion molecules and functional outcome after ischemic stroke: A Mendelian randomization study. J Stroke Cerebrovasc Dis. doi:10.1016/j.jstrokecerebrovasdis.2023.107136.
Cao L, Liu D, Karhunen V, …, Wang M (2023). Circulating macrophage colony-stimulating factor levels and stroke: A Mendelian randomization study. J Stroke Cerebrovasc Dis. doi:10.1016/j.jstrokecerebrovasdis.2023.107050.
Huang J, Su B, Karhunen V, …, Tzoulaki I, Dehghan A (2023). Inflammatory Diseases, Inflammatory Biomarkers, and Alzheimer Disease: An Observational Analysis and Mendelian Randomization. Neurology. doi:10.1212/wnl.0000000000201489.
Yuan S, Karhunen V, Larsson S, Gill D (2022). Anthropometric Traits and Risk of Mitral Valve Prolapse: A Mendelian Randomization Study. Circ Genom Precis Med. doi:10.1161/circgen.122.003830.
Ryan DK, Karhunen V, …, Gill D (2022). Genetic evidence for protective effects of angiotensin-converting enzyme against Alzheimer disease but not other neurodegenerative diseases in European populations. Neurol Genet. doi:10.1212/nxg.0000000000200014.
Neumann A, Nolte IM, Ahluwalia TS, …, Karhunen V, …, Tiemeier H (2022). A genome-wide association study of total child psychiatric problems scores. PLoS One. doi:10.1371/journal.pone.0273116.
Zhao SS, Rajasundaram S, Karhunen V, Alam U, Gill D (2022). Sodium-glucose transporter 1 inhibition and gout: Mendelian randomisation study. Semin Arthritis Rheum. doi:10.1016/j.semarthrit.2022.152058.
Wielscher M, Mandaviya PR, Kuehnel B, …, Karhunen V, …, Järvelin MR (2022). DNA methylation signature of chronic low-grade inflammation and its role in cardio-respiratory diseases. Nat Commun. doi:10.1038/s41467-022-29792-6.
Said S, Pazoki R, Karhunen V, …, Dehghan A (2022). Genetic analysis of over half a million people characterises C-reactive protein loci. Nat Commun. doi:10.1038/s41467-022-29650-5.
Jami ES, Hammerschlag AR, Ip HF, …, Karhunen V, …, Middeldorp CM (2022). Genome-wide Association Meta-analysis of Childhood and Adolescent Internalizing Symptoms. J Am Acad Child Adolesc Psychiatry. doi:10.1016/j.jaac.2021.11.035.
Pervjakova N, Moen GH, Borges MC, …, Karhunen V, …, Mägi R (2022). Multi-ancestry genome-wide association study of gestational diabetes mellitus highlights genetic links with type 2 diabetes. Hum Mol Genet. doi:10.1093/hmg/ddac050.
Zhao SS, Karhunen V, Morris AP, Gill D (2022). ADAMTS5 as a therapeutic target for osteoarthritis: Mendelian randomisation study. Ann Rheum Dis. doi:10.1136/annrheumdis-2021-222007.
Bond TA, Richmond RC, Karhunen V, …, Lawlor DA, Järvelin MR (2022). Exploring the causal effect of maternal pregnancy adiposity on offspring adiposity: Mendelian randomisation using polygenic risk scores. BMC Med. doi:10.1186/s12916-021-02216-w.
Bouras E, Karhunen V, Gill D, …, Tsilidis KK (2022). Circulating inflammatory cytokines and risk of five cancers: a Mendelian randomization analysis. BMC Med. doi:10.1186/s12916-021-02193-0.
Hawe JS, Wilson R, Schmid KT, …, Karhunen V, …, Chambers JC (2022). Genetic variation influencing DNA methylation provides insights into molecular mechanisms regulating genomic function. Nat Genet. doi:10.1038/s41588-021-00969-x.
Ip HF, van der Laan CM, Krapohl EML, …, Karhunen V, …, Bartels M, Nivard MG, Boomsma DI (2021). Genetic association study of childhood aggression across raters, instruments, and age. Transl Psychiatry. doi:10.1038/s41398-021-01480-x.
Daghlas I, Karhunen V, Ray D, …, Gill D (2021). Genetic Evidence for Repurposing of GLP1R (Glucagon-Like Peptide-1 Receptor) Agonists to Prevent Heart Failure. J Am Heart Assoc. doi:10.1161/JAHA.120.020331.
Fatumo S, Karhunen V†, Chikowore T, …, Gill D† (2021). Metabolic Traits and Stroke Risk in Individuals of African Ancestry: Mendelian Randomization Analysis. Stroke. doi:10.1161/STROKEAHA.121.034747. †Corresponding authors.
Gill D, Zuber V, Dawson J, …, Karhunen V, …, Elliott P (2021). Risk factors mediating the effect of body mass index and waist-to-hip ratio on cardiovascular outcomes: Mendelian randomization analysis. Int J Obes (Lond). doi:10.1038/s41366-021-00807-4.
Cartwright R, Franklin L, Tikkinen KAO, …, Karhunen V , …, Walley A (2021). Genome Wide Association Study Identifies Two Novel Loci Associated with Female Stress and Urgency Urinary Incontinence. J Urol. doi:10.1097/JU.0000000000001822.
Malik R, Georgakis MK, Vujkovic M, …, Karhunen V, …, Gill D (2021). Relationship Between Blood Pressure and Incident Cardiovascular Disease: Linear and Nonlinear Mendelian Randomization Analyses. Hypertension. doi:10.1161/HYPERTENSIONAHA.120.16534.
Rajula HSR, Manchia M, Agarwal K, …, Karhunen V, …, Middeldorp CM (2021). Overview of CAPICE-Childhood and Adolescence Psychopathology: unravelling the complex etiology by a large Interdisciplinary Collaboration in Europe-an EU Marie Skłodowska-Curie International Training Network. Eur Child Adolesc Psychiatry. doi:10.1007/s00787-020-01713-2.
Crawford AA, Bankier S, Altmaier E, …, Karhunen V, …, Walker BR (2021). Variation in the SERPINA6/SERPINA1 locus alters morning plasma cortisol, hepatic corticosteroid binding globulin expression, gene expression in peripheral tissues, and risk of cardiovascular disease. J Hum Genet. doi:10.1038/s10038-020-00895-6.
Gomez-Alonso MDC, Kretschmer A, Wilson R, …, Karhunen V, …, Waldenberger M (2021). DNA methylation and lipid metabolism: an EWAS of 226 metabolic measures. Clin Epigenetics. doi:10.1186/s13148-020-00957-8.
Ryan DK, Karhunen V, Walker DJ, Gill D. (2021) Inhibition of interleukin 6 signalling and renal function: a Mendelian randomization study. Br J Clin Pharmacol. doi:10.1111/bcp.14725.
Gill D, Cameron AC, Burgess S, …, Karhunen V, …, Tzoulaki I (2021). Urate, Blood Pressure, and Cardiovascular Disease: Evidence From Mendelian Randomization and Meta-Analysis of Clinical Trials. Hypertension. doi:10.1161/HYPERTENSIONAHA.120.16547.
Gill D, Arvanitis M, Carter P, …, Karhunen V, …, Burgess S (2020). ACE inhibition and cardiometabolic risk factors, lung ACE2 and TMPRSS2 gene expression, and plasma ACE2 levels: a Mendelian randomization study. R Soc Open Sci. doi:10.1098/rsos.200958.
Nuotio ML, Pervjakova N, Joensuu A, Karhunen V, …, Perola M (2020). An epigenome-wide association study of metabolic syndrome and its components. Sci Rep. doi:10.1038/s41598-020-77506-z.
Robinson O, Carter AR, Ala-Korpela M, …, Karhunen V, …, Vineis P (2020). Metabolic profiles of socio-economic position: a multi-cohort analysis. Int J Epidemiol. doi:10.1093/ije/dyaa188.
Allegrini AG, Karhunen V, Coleman JRI, …, Pingault JB, Plomin R (2020). Multivariable G-E interplay in the prediction of educational achievement. PLoS Genet. doi:10.1371/journal.pgen.1009153.
Vogelezang S, Bradfield JP, Ahluwalia TS, …, Karhunen V, …, Felix JF (2020). Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits. PLoS Genet. doi:10.1371/journal.pgen.1008718.
Rauschert S, Melton PE, Heiskala A, Karhunen V, …, Huang RC (2020). Machine Learning-Based DNA Methylation Score for Fetal Exposure to Maternal Smoking: Development and Validation in Samples Collected from Adolescents and Adults. Environ Health Perspect. doi:10.1289/EHP6076.
Loftfield E, Herzig KH, Caporaso JG, …, Karhunen V, …, Sinha R (2020). Association of Body Mass Index with Fecal Microbial Diversity and Metabolites in the Northern Finland Birth Cohort. Cancer Epidemiol Biomarkers Prev. doi:10.1158/1055-9965.EPI-20-0824.
Gill D, Georgakis MK, Zuber V, Karhunen V, …, Dichgans M (2020). Genetically Predicted Midlife Blood Pressure and Coronary Artery Disease Risk: Mendelian Randomization Analysis. J Am Heart Assoc doi:10.1161/JAHA.120.016773.
Akingbuwa WA, Hammerschlag AR, Jami ES, …, Karhunen V, …, Middeldorp CM (2020). Genetic Associations Between Childhood Psychopathology and Adult Depression and Associated Traits in 42 998 Individuals: A Meta-Analysis. JAMA Psychiatry. doi:10.1001/jamapsychiatry.2020.0527.
Lee MA, McMahon G, Karhunen V, …, Timpson NJ (2020). Common Variation at 16p11.2 Is Associated With Glycosuria in Pregnancy: Findings From a Genome-Wide Association Study in European Women. Hum Mol Genet. doi:10.1093/hmg/ddaa054.
Couto Alves A, De Silva NMG, Karhunen V, …, Grant SFA, Sebert S, McCarthy MI, Järvelin MR (2019). GWAS on longitudinal growth traits reveals different genetic factors influencing infant, child, and adult BMI. Science Advances. doi:10.1126/sciadv.aaw3095.
Gallagher CS, Mäkinen N, Harris HR, …, Karhunen V, …, Morton CC (2019). Genome-wide association and epidemiological analyses reveal common genetic origins between uterine leiomyomata and endometriosis. Nat Commun. doi:10.1038/s41467-019-12536-4.
Bradfield JP, Vogelezang S, Felix JF, …, Karhunen V, …, Grant SFA (2019). A Trans-ancestral Meta-Analysis of Genome-Wide Association Studies Reveals Loci Associated with Childhood Obesity. Hum Mol Genet. doi:10.1093/hmg/ddz161.
Bond TA, Karhunen V, Wielscher M, …, Järvelin MR (2019). Exploring the role of genetic confounding in the association between maternal and offspring body mass index: evidence from three birth cohorts. Int J Epidemiol. doi:10.1093/ije/dyz095.
Leal LG, David A, Järvelin MR, …, Karhunen V, …, Sternberg MJE (2019). Identification of disease-associated loci using machine learning for genotype and network data integration. Bioinformatics. doi:10.1093/bioinformatics/btz310.
Middeldorp CM, Felix JF, Mahajan A, …, Karhunen V, …, McCarthy MI (2019). The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia: design, results and future prospects. Eur J Epidemiol. doi:10.1007/s10654-019-00502-9.
Perkiömäki N, Auvinen J, Tulppo MP, …, Karhunen V, …, Kiviniemi AM (2019). Childhood growth patterns and cardiovascular autonomic modulation in midlife: Northern Finland 1966 Birth Cohort Study. Int J Obes (London). doi:10.1038/s41366-019-0333-0.
Karlsson Linner R, Biroli P, Kong E, …, Karhunen V, …, Beauchamp JP (2019). Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences. Nat Genet. doi:10.1038/s41588-018-0309-3.
Lowry E, Rautio N, Karhunen V, …, Järvelin MR (2018). Understanding the complexity of glycaemic health: systematic bio-psychosocial modelling of fasting glucose in middle-age adults; a DynaHEALTH study. Int J Obes (Lond). doi:10.1038/s41366-018-0175-1.
Parmar P, Lowry E, Cugliari G, …, Karhunen V, …, Järvelin MR, Sebert S (2018). Association of maternal prenatal smoking GFI1-locus and cardio-metabolic phenotypes in 18,212 adults. EBioMedicine. doi:10.1016/j.ebiom.2018.10.066.
Ligthart S, Vaez A, Vosa U, …, Karhunen V, …, Dehghan A, Alizadeh BZ (2018). Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders. Am J Hum Genet. doi:10.1016/j.ajhg.2018.09.009.
Beckmeyer-Borowko A, Imboden M, Rezwan FI, … Karhunen V, …, Probst-Hensch NM (2018). SERPINA1 methylation and lung function in tobacco-smoke exposed European children and adults: a meta-analysis of ALEC population-based cohorts. Respir Res. doi:10.1186/s12931-018-0850-8.
Zhou A, Taylor AE, Karhunen V, …, Hyppönen E (2018). Habitual coffee consumption and cognitive function: a Mendelian randomization meta-analysis in up to 415,530 participants. Sci Rep. doi:10.1038/s41598-018-25919-2.
Bonfiglio F, Henstrom M, Nag A, … Karhunen V, …, D’Amato M (2018). A GWAS meta‐analysis from 5 population‐based cohorts implicates ion channel genes in the pathogenesis of irritable bowel syndrome. Neurogastroenterol Motil, doi:10.1111/nmo.13358.
Metrustry SJ, Karhunen V, Edwards MH, …, Valdes AM (2018). Metabolomic signatures of low birthweight: Pathways to insulin resistance and oxidative stress. PLoS One. doi:10.1371/journal.pone.0194316.
Maddock J, Zhou A, Cavadino A, … Karhunen V, …, Hyppönen E (2017). Vitamin D and cognitive function: A Mendelian randomisation study. Sci Rep. doi:10.1038/s41598-017-13189-3.
Schierding W, Antony J, Karhunen V, …, Cutfield WS (2017). GWAS on prolonged gestation (post-term birth): analysis of successive Finnish birth cohorts. J Med Genet. doi:10.1136/jmedgenet-2017-104880.
Warrington NM, Richmond R, Fenstra B, … Karhunen V, …, Evans DM, Lawlor DA (2017). Maternal and fetal genetic contribution to gestational weight gain. Int J Obes. doi:10.1038/ijo.2017.248.
Bonfiglio F, Hysi PG, Ek W, … Karhunen V, …, D’Amato M (2017). A meta-analysis of reflux genome-wide association studies in 6750 Northern Europeans from the general population. Neurogastroenterol Motil. doi:10.1111/nmo.12923.
Perkiömäki N, Auvinen J, Tulppo MP, … Karhunen V, …, Kiviniemi AM (2016). Association between Birth Characteristics and Cardiovascular Autonomic Function at Mid-Life. PLoS One. doi:10.1371/journal.pone.0161604.
Okbay A, Baselmans BM, De Neve JE, … Karhunen V, …, Cesarini D (2016). Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses. Nat Genet. doi:10.1038/ng.3552.